Extreme itching in my palms and soles at night I have been experiencing extreme itching in my palms and soles at night since last 4 months. There r no rashes or visible reasons for the itch and is never there throughout the day. I have heard about such symptoms in Cholestatic Liver Disease. I had my Gall bladder removed 5 years back. Is this anyway related to it. Please advice as I am spending sleepless night s due to this terrible itch.